The Andrews Research Group

Mittra, B, Laranjeira-Silva MF, Miguel DC, de Menezes JP and Andrews, NW. The iron-dependent mitochondrial superoxide dismutase SODA regulates Leishmania virulence. J. Biol. Chem., pii: jbc.M116.772624. doi: 10.1074/jbc.M116.772624, 2017. Link

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De Menezes, JP, Koushik, A, Das, S, Guven, C, Siegel, A, Laranjeira-Silva, MF, Losert, W and Andrews, NW. Leishmaniainfection inhibits macrophage motility by altering  F-actin dynamics and the expression of adhesion complex proteins. Cell. Microbiol., doi: 10.1111/cmi.12668, 2017. Link

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Castro-Gomes, T, Corrotte, M, Tam, C, and Andrews, NW. Plasma membrane repair is regulated extracellularly by proteases released from lysosomes. PLoS One, 11(3):e0152583. doi: 10.1371/journal.pone.0152583, 2016. Link

 

Mittra, M, Bezerra de Menezes, JP, Larangeira-Silva, MF, Jensen, J, Michailowsky, V, and Andrews, NW. A trypanosomatid iron transporter that regulates mitochondrial function is required for Leishmania amazonensis virulence. PLoS Pathogens, 12(1):e1005340, 2016. Link

 

Miller, H, Castro-Gomes, T, Corrotte, M, Tam, C., Maugel, TK, Andrews, NW and Song, W. Lipid raft-dependent plasma membrane repair interferes with the activation of B-lymphocytes. J. Cell Biol., 211: 1193-1205, 2015. Link

 

Renberg, RL, Yuan, X, Samuel, T, Miguel, DC, Hamza, I, Andrews, NW and Flannery, AR. The heme transport capacity of LHR1 determines the extent of virulence in Leishmania amazonensis. PLoS Neglected Tropical Diseases, doi: 10.1371/journal.pntd.0003804, 2015. Link

 

Corrotte M, Castro-Gomes T, Koushik AB, Andrews NW. Approaches for plasma membrane wounding and assessment of lysosome-mediated repair responses. Methods in Cell Biol. 2015;126:139-58. doi: 10.1016/bs.mcb.2014.11.009. Epub 2015 Jan 14. Link

 

Fernandes MC, Corrotte M, Miguel DC, Tam C, Andrews NW. The exocyst is required for trypanosome invasion and the repair of mechanical plasma membrane wounds. J Cell Sci. 2015 Jan 1;128(1):27-32. doi: 10.1242/jcs.150573. Epub 2014 Nov 6. Link

 

Andrews NW, Almeida PE, Corrotte M. Damage control: cellular mechanisms of plasma membrane repair. Trends Cell Biol. 2014 Dec;24(12):734-42. doi: 10.1016/j.tcb.2014.07.008. Epub 2014 Aug 20. Link

 

Castro-Gomes T, Koushik AB, Andrews NW. ESCRT: nipping the wound in the bud? Trends Biochem Sci. 2014 Jul;39(7):307-9. doi: 10.1016/j.tibs.2014.06.001. Epub 2014 Jun 20. Link

 

Ben-Othman R, Flannery AR, Miguel DC, Ward DM, Kaplan J, Andrews NW. Leishmania-mediated inhibition of iron export promotes parasite replication in macrophages. PLoS Pathog. 2014 Jan 30;10(1):e1003901. doi: 10.1371/journal.ppat.1003901. eCollection 2014 Jan. Link

 

Hissa B, Pontes B, Roma PM, Alves AP, Rocha CD, Valverde TM, Aguiar PH, Almeida FP, Guimarães AJ, Guatimosim C, Silva AM, Fernandes MC, Andrews NW, Viana NB, Mesquita ON, Agero U, Andrade LO. Membrane cholesterol removal changes mechanical properties of cells and induces secretion of a specific pool of lysosomes. PLoS One. 2013 Dec 20;8(12):e82988. doi: 10.1371/journal.pone.0082988. eCollection 2013. Link

 

Corrotte M, Almeida PE, Tam C, Castro-Gomes T, Fernandes MC, Millis BA, Cortez M, Miller H, Song W, Maugel TK, Andrews NW. Caveolae internalization repairs wounded cells and muscle fibers. Elife. 2013 Sep 17;2:e00926. doi: 10.7554/eLife.00926. Link

 

Flannery AR, Renberg RL, Andrews NW. Pathways of iron acquisition and utilization in Leishmania. Curr Opin Microbiol. 2013 Dec;16(6):716-21. doi: 10.1016/j.mib.2013.07.018. Epub 2013 Aug 17. Review. Link

 

Mittra B, Andrews NW. IRONy OF FATE: role of iron-mediated ROS in Leishmania differentiation. Trends Parasitol. 2013 Oct;29(10):489-96. doi: 10.1016/j.pt.2013.07.007. Epub 2013 Aug 12. Review. Link

 

Miguel DC, Flannery AR, Mittra B, Andrews NW. Heme uptake mediated by LHR1 is essential for Leishmania amazonensis virulence. Infect Immun. 2013 Oct;81(10):3620-6. doi: 10.1128/IAI.00687-13. Epub 2013 Jul 22. Link

 

Mittra B, Cortez M, Haydock A, Ramasamy G, Myler PJ, Andrews NW. Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels. J Exp Med. 2013 Feb 11;210(2):401-16. doi: 10.1084/jem.20121368. Epub 2013 Feb 4. Link

 

Huynh C, Yuan X, Miguel DC, Renberg RL, Protchenko O, Philpott CC, Hamza I, Andrews NW. Heme uptake by Leishmania amazonensis is mediated by the transmembrane protein LHR1. PLoS Pathog. 2012;8(7):e1002795. doi: 10.1371/journal.ppat.1002795. Epub 2012 Jul 12. Link

 

Andrews NW. Oxidative stress and intracellular infections: more iron to the fire. J Clin Invest. 2012 Jul;122(7):2352-4. doi: 10.1172/JCI64239. Epub 2012 Jun 25. Link

 

Fernandes MC, Andrews NW. Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence. FEMS Microbiol Rev. 2012 May;36(3):734-47. doi: 10.1111/j.1574-6976.2012.00333.x. Epub 2012 Mar 13. Review. Link

 

Fernandes MC, Andrade LR, Andrews NW, Mortara RA. Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion. Mem Inst Oswaldo Cruz. 2011 Dec;106(8):1014-6. Erratum in: Mem Inst Oswaldo Cruz. 2012 Feb;107(1). doi: 10.1590/S0074-02762012000100022. Link

 

Corrotte M, Fernandes MC, Tam C, Andrews NW. Toxin pores endocytosed during plasma membrane repair traffic into the lumen of MVBs for degradation. Traffic. 2012 Mar;13(3):483-94. doi: 10.1111/j.1600-0854.2011.01323.x. Epub 2012 Jan 24. Link

 

Cortez M, Huynh C, Fernandes MC, Kennedy KA, Aderem A, Andrews NW. Leishmania promotes its own virulence by inducing expression of the host immune inhibitory ligand CD200. Cell Host Microbe. 2011 Jun 16;9(6):463-71. doi: 10.1016/j.chom.2011.04.014. Link

 

Flannery AR, Huynh C, Mittra B, Mortara RA, Andrews NW. LFR1 ferric iron reductase of Leishmania amazonensis is essential for the generation of infective parasite forms. J Biol Chem. 2011 Jul 1;286(26):23266-79. doi: 10.1074/jbc.M111.229674. Epub 2011 May 10. Link

 

Fernandes MC, Cortez M, Flannery AR, Tam C, Mortara RA, Andrews NW. Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion. J Exp Med. 2011 May 9;208(5):909-21. doi: 10.1084/jem.20102518. Epub 2011 May 2. Link

 

Flannery AR, Czibener C, Andrews NW. Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes. J Cell Biol. 2010 Nov 1;191(3):599-613. doi: 10.1083/jcb.201003021. Link

 

Albertti LA, Macedo AM, Chiari E, Andrews NW, Andrade LO. Role of host lysosomal associated membrane protein (LAMP) in Trypanosoma cruzi invasion and intracellular development. Microbes Infect. 2010 Sep;12(10):784-9. doi: 10.1016/j.micinf.2010.05.015. Epub 2010 Jun 16. Link

 

Tam C, Idone V, Devlin C, Fernandes MC, Flannery A, He X, Schuchman E, Tabas I, Andrews NW. Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair. J Cell Biol. 2010 Jun 14;189(6):1027-38. doi: 10.1083/jcb.201003053. Epub 2010 Jun 7. Link

 

Colvin RA, Means TK, Diefenbach TJ, Moita LF, Friday RP, Sever S, Campanella GS, Abrazinski T, Manice LA, Moita C, Andrews NW, Wu D, Hacohen N, Luster AD. Synaptotagmin-mediated vesicle fusion regulates cell migration. Nat Immunol. 2010 Jun;11(6):495-502. doi: 10.1038/ni.1878. Epub 2010 May 16. Link

 

Jacques I, Andrews NW, Huynh C. Functional characterization of LIT1, the Leishmania amazonensis ferrous iron transporter. Mol Biochem Parasitol. 2010 Mar;170(1):28-36. doi: 10.1016/j.molbiopara.2009.12.003. Epub 2009 Dec 16. Link